pentobarbital will minimize the level or result of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or influence of tramadol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. Decreased AUC of tramadol along with the Energetic metabolite (O-desmethyltramadol)